Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2020 , Vol 11, Issue 4
Factors Affecting Parathormone Response To Low Serum Vitamin D Levels
Tuğba Aydın1
1Sağlık Bilimleri Üniversitesi, İstanbul Fizik Tedavi ve Rehabilitasyon SUAM, Fizik Tedavi ve Rehabilitasyon, İstanbul, Türkiye DOI : 10.31067/0.2020.322 Objective: The aim of the study is to determine the factors affecting parathormone (PTH) response induced in patients with low serum 25(OH) vitamin D levels.

Materials and methods: This is a retrospective descriptive study. The patients whom serum 25(OH) vitamin D and PTH levels were examined together were included in our study in Istanbul in Physical Therapy Rehabilitation Education and Research Hospital between 2015 and 2019. Patients with 25(OH) vitamin D values lower than 30 ng/mL were included in the study. The patients 17 years and under; the patients with abnormal creatinine, albumin, calcium and phosphorus levels and the patients with PTH levels lower than 12 pg/mL were excluded from the study. Age, sex, seasonal hospital admission, serum 25(OH) vitamin D and PTH levels were examined.

Results: The mean age of the 334 patients included in the study was 49.1±17.7 years. The mean serum 25(OH) vitamin D level was 14.5±7.6 ng/mL and the mean PTH level was 49.3±26.5 pg/mL. 34.4% of the patients had severe 25(OH) vitamin D deficiency, 37.4% of the patients had 25(OH) vitamin D deficiency and 28.1% of the patients had 25(OH) vitamin D insufficiency. Hyperparathyroidism was found in 6.3% of all cases. Hyperparathyroidism was found to be significantly more frequent in patients with severe 25(OH) vitamin D deficiency. There was a negative correlation between serum PTH and 25(OH) vitamin D levels. There was a positive correlation between age and serum PTH levels. There was no relationship with 25(OH) vitamin D level, gender and seasonal distribution.

Conclusion: Low 25(OH) vitamin D induced PTH elevation is not only dependent on vitamin D levels, but also age. PTH levels were found to be higher in patients with low vitamin D while age increased. Keywords : 25(OH) vitamin D, parathyroid hormone, parathormone response