Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2019 , Vol 10, Issue 4
Investigation of Endothelial Dysfunction and The Risk of Atherosclerosis In Patients With Obstructive Sleep Apnea Syndrome
Elçin Aydın1,Cihan Altın2,Birsen Şahin Satılmış3,Erkan Eşki4,Mustafa Agah Tekindal5,Muhteşem Ağıldere6
1Başkent Üniversitesi Tıp Fakültesi, Radyoloji Anabilim Dalı, İzmir, Türkiye
2Başkent Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye
3Başkent Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, İzmir, Türkiye
4Başkent Üniversitesi Tıp Fakültesi, Kulak, Burun, Boğaz Anabilim Dalı, İzmir, Türkiye
5Selçuk Üniversitesi, Biyoistatistik Anabilim Dalı, Konya, Türkiye
6Başkent Üniversitesi Tıp Fakültesi, Radyoloji Anabilim Dalı, Ankara, Türkiye
DOI : 10.31067/0.2019.213 Purpose: To investigate endothelial dysfunction and pre-atherosclerosis in patients with Obstructive Sleep Apnea Syndrome (OSAS) by using several parameters including Brachial Artery Flow-Mediated Vasodilation (BAFMV), Carotid Intima-Media Thickness (CIMT), Mean Platelet Volume (MPV) and Epicardial Fat Thickness (EFT). Patients with OSAS were classified according to the Apnea-Hypopnea Index (AHI).

Patients and Methods: OSAS patients who have 5 or more AHI score were enrolled in the study. Patients with hypertension, hyperlipidemia, diabetes mellitus and cardiovascular diseases were excluded. Patients were classified as mild (5-10), moderate (16-30) and severe (>30) according to AHI. These groups were compared to each other in terms of endothelial dysfunction and pre-atherosclerosis markers including BAFMV, CIMT, MPV and EFT. Groups were compared statistically by using either Student"s T-Test or Mann Whitney?U test.

Results: Our study population consists of 23 patients with OSAS (16 male, 7 female) with the mean age of 46.30±9.51 years ranging from 31-65 years. There were no significant differences in all parameters between the mild (5-10), moderate (16-30) and severe (>30) groups according to AHI.

Conclusion: It is well known that patients with OSAS have an increased cardiovascular risk. In our study, no differences were shown between the progression of the disease and endothelial dysfunction and pre-atherosclerosis markers. Keywords : Endothelial dysfunction, pre-atherosclerosis, obstructive sleep apnea syndrome