Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2019 , Vol 10, Issue 4
Clinical Importance of Mean Platelet Volume In Children With Family Mediterranean Fever
Dilek Doğruel1,Rabia Miray Kışla Ekinci2,Sibel Balcı2,Mustafa Yılmaz2,Derya Ufuk Altıntaş1
1Çukurova Üniversitesi, Çocuk Alerji ve İmmünoloji, Adana, Türkiye
2Çukurova Üniversitesi, Çocuk Romatoloji, Adana, Türkiye
DOI : 10.31067/0.2019.208 Objectives: Familial Mediterranean Fever (FMF) is an autosomal recessive inflammatory disease characterised by recurrent involvement of serous membranes. It has been shown that the mean platelet volume (MPV) could be used as a marker in many inflammatory diseases. In this study, we investigated the genetic mutation in children with FMF and changes in MPV in attack and attack-free periods.

Patients and Methods: The study included 110 children diagnosed with FMF based on the Tel-Hashomer Criteria. Demographic features, results of genetic analyses, complete blood count parameters, MPV levels, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) results were evaluated retrospectively. Data of the patients were recorded separately based on the acute attack and attack-free periods under treatment.

Results: The mean platelet volume was found to be 8,55±1,51 fL in the attack period and 9,61±1,18 fL in the attack-free period. The mean platelet volume was significantly lower in patients with an attack period compared to the patients at an attack-free period (p=0.000). The platelet and leukocyte count, ESR, CRP were statistically significantly higher in the attack period compared to the attack-free period (p=0.000).

Conclusion: The mean platelet volume is decreased in patients with attack period and it may be a useful parameter in determining(timing) the attack. It is important that clinicians use this parameter when evaluating the hemogram result. Keywords : Familial Mediterranean Fever, Inflammation, Mean Platelet Volume