Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2019 , Vol 10, Issue 3
Proteomics In Thyroid Pathology
Yasemin Uçal1,Aysel Ozpinar1
1Acıbadem Mehmet Ali Aydınlar Üniversitesi, Tıbbi Biyokimya Anabilim Dalı, Istanbul, Türkiye DOI : 10.31067/0.2019.171 Thyroid cancer is the most common endocrine malignancy, of which the incidence has increased worldwide in the past years. The most reliable and inexpensive method for establishing the histopathological diagnosis of thyroid nodules is Fine Needle Aspiration Biopsy (FNAB). However, the lack of discrimination (distinctive) criteria in differential diagnosis leads to the failure of the successful diagnosis of some nodules. For this purpose, several molecular techniques have been developed and several molecules were targeted for the differential diagnosis of thyroid nodules. However, genetic mutations or cell surface markers that might contribute to the differential diagnosis are not widely used due to the differences in prevalence.

In the recent years, rapidly developing proteomic techniques are thought to contribute to the differential diagnosis in thyroid pathology as proteomics provide information about the structure, location, quantity, posttranslational modifications and protein-protein interactions of the proteins found in certain places in the nodules. In this review, we will focus on the clinical applications of proteomic techniques on thyroid tissues and emphasize the clinical usage of potential biomarkers that may contribute to the differential diagnosis. Keywords : Thyroid pathology, proteomics, mass spectrometry