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The Effect of Additives In Urine Tubes On Biochemical Analytes
Arzu Kösem1,Sevilay Sezer1,Canan Topçuoğlu1,Turan Turhan1
1Ankara Numune Training and Research Hospital, Clinical Biochemistry Laboratory, Ankara, Turkey Purpose: The use of urine tubes containing preservatives for urine analysis has made a new era. Compounds in tubes with preservatives can be listed as follows: Sodium propionate (94%), ethylparaben (5.6%) and chlorhexidine (0.4%). The aim of this study was to test the effectiveness of urine tubes with preservative (Becton- Dickinson, Franklin Lakes, USA) on some biochemical parameters.

Patients and Methods: The 24-h urine samples (n=118) obtained from the outpatient clinic were sent for routine urine analysis. Urine samples were divided into two tubes; urine tubes with preservatives and urine tubes without preservatives. Six biochemical parameters (protein, calcium, urea, phosphorus, creatinine, microalbumin) were measured on a Beckman Coulter AU680 analyzer.

Results: The results of the phosphorus in the two urine samples were decreased significantly at all time points in the stability studies (p=0.02, p<0.01).

Conclusion: It can be concluded that tubes containing preservatives could be used to analyze biochemical parameters. However, measurement of urine phosphorus with tubes containing preservatives should be performed immediately after delivery to the laboratory. Keywords : Additive, biochemical test, stability, urine tube; urine