Acıbadem Üniversitesi Sağlık Bilimleri Dergisi Online Early
The Role of Circulating Cell-Free Mitochondrial Dna In Systemic Circulation and Its Effect On Diseases Pathogenesis
Ayşe Tülay Aydınoğlu1,Evrim Aksu Mengeş1,Burcu Balcı Hayta1
1Hacettepe Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Ankara, Türkiye Mitochondria are multi-functional organelles with many essential roles in the maintenance of cell viability as well as ATP production by oxidative phosphorylation. One of the most important features of this organelle that contributes to cell viability is its own genetic system. Mitochondrial DNA (mtDNA), which is located in the mitochondrial matrix under normal physiological conditions, is released into the extracellular matrix and enters the systemic circulation in case of an organelle and/or a cellular damage. Recent studies have focused on the role of mtDNA in circulation and its association with diseases. Circulating cell-free mtDNA (ccf-mtDNA) is regarded as a Damage Associated Molecular Pattern (DAMP) and recognised by the Pattern Recognition Receptors (PRRs). They play a fundamental role in initiating the pro-inflammatory response. In this review, the mechanisms of ccf-mtDNA-induced inflammatory pathways in systemic circulation and the effect of ccf-mtDNA on diseases pathogenesis will be discussed. Keywords : ccf-mtDNA, systemic circulation, inflammation