Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2015 , Vol 6, Issue 1
Prognostic Factors In Gastric Cancer Patients Treated With Adjuvant Chemoradiotherapy
Vildan Kaya1, Aylin Fidan Korcum2, Mustafa Yıldırım3, Melek Gamze Aksu2, Hasan Mutlu4, Beyza Şirin Özdemir2, Ali Aydın Yavuz2
1Süleyman Demirel Üniversitesi Tıp Fakültesi Hastanesi, Radyasyon Onkolojisi Anabilim Dalı, Isparta, Türkiye
2Akdeniz Üniversitesi Tıp Fakültesi, Radyasyon Onkolojisi, Antalya, Türkiye
3Medikal Park Gaziantep Hastanesi, Tıbbi Onkoloji, Gaziantep, Türkiye
4Akdeniz Üniversitesi Tıp Fakültesi, Tıbbi Onkoloji, Antalya, Türkiye
Aim: Gastric cancer is a progressive disease. Although surgery is the only curative treatment, recurrence can occur. In our study, clinicopathologic prognostic factors are investigated in gastric cancer patients who underwent adjuvant chemoradiotherapy.

Material and Method: The patients that underwent postoperative 5-FU based chemotherapy and concurrent radiotherapy between the years of 2008-2011 in Medical School, have been examined.

Results: In this study, 25 female (31.6%) and 54 male patients (68.4%) from a total of 79 patients are included. The main follow-up period was 21.5±14.1 (3.8- 87.6) months. Patients 2-year survival and 3-year survival rate was found as 63.8% and 39.3%, respectively. In research of overall survival with multivariate analyses, no relationship was established between survival and gender, age, depth of tumor invasion, histological grade and histological subtype (p=0.358, p=0.156, p=0.223, p=0.939). In contrast, statistical significance was found between overall survival and lymph node status of patients and stage of disease (p=0.002, p=0.003).

Conclusions: In our study, which is consistent with literature, it was revealed that the stage of disease and lymph node status are the most important prognostic factors for both disease free survival and overall survival. Keywords : gastric cancer, chemoradiotherapy, prognosis, stage, lymph node