Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2013 , Vol 4, Issue 4
Two Cases With Pulmonary Langerhans' Cell Histiocytosis and Review of The Literature
Esra Yazar, Selim Kahraman, Akif Özgül, Nur Büyükpınarbaşı, Veysel Yılmaz
Yedikule Göğüs Hastalıkları Hastanesi, Göğüs Hasdtalıkları, İstanbul, Türkiye The etiology and frequency of pulmonary langerhans'cell histiocytosis (PLCH) is not exactly known and it is a rare pulmonary parenchymal disease. We investigated two cases (first case aged 19 yr male, second case aged 22 yr male) which we have diagnosed in our clinic. Both of the patients were smoker as evidence implicating tabacco smoke in the etiology (8p/year and 30p/year, respectively). The presentation symptom in the first case was dyspnea and in the other case was constitutional symptoms and hemoptysis. The DLCO was low in both cases. Whereas in the first case a restrictive pattern of pulmonary function disorder was observed in the second case there was an obstructive pattern with incrased lung volumes. Appearence of the thorax computed tomography of both patients was consistent with PLCH. The diagnosis was made by immunohistochemical staining of transbronchial biopsy and by high CD-1a positive langerhans' cell ratio (5%) in bronchoalveolar lavage in the first and second case, respectively. The diagnosis of both patients was made with less invasive procedure due to the typically radiologic findings and age. An open lung biopsy is not necessary in patients with typically clinic and radiologic findings. Keywords : pulmonary langerhans'cell histiocytosis, radiologic manifestation, diagnosis